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A Translocation Between Chromosomes 9 and 22 Produces the BCR-ABL α\alpha

Question 5

Multiple Choice

A translocation between chromosomes 9 and 22 produces the BCR-ABL fusion gene.This is the transforming event in 90% of individuals with chronic myelogenous leukemia (CML) .Which one of the following statements regarding the protein product of this fusion gene is correct?


A) It is a nuclear phosphoprotein that deregulates DNA syntheses and increases cellular proliferation.
B) It is a cytoplasmic tyrosine kinase that activates a number of signaling pathways leading to growth and inhibition of apoptosis.
C) It is a mitotic control gene that allows cells to move through the cell cycle and contribute to the autonomous growth of cancer.
D) It interacts with other proteins,such as α\alpha - and β\beta -catenin,involved in cell-cell interactions in epithelial cells to form polyps.

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