Which of the following could account for drug toxicity following a prescribed dose?

Question

Quizplus · Accepted Answer

Decreased renal elimination can result in a buildup of drug concentration in the body, leading to drug toxicity even when the prescribed dose has been taken.

Answer: C 
 Using a different route of administration than what is typically used for a drug can alter the pharmacokinetics of the drug, leading to higher-than-intended drug concentrations and an increased risk of toxicity.

Answer: D 
 Central nervous system disease can impact drug metabolism, potentially leading to impaired drug clearance and toxic drug concentrations even at a prescribed dose.

Therefore, the best choice(s) are A, C, and D.

Which of the Following Could Account for Drug Toxicity Following