Why Is Bone Disease a Consequence of Chronic Kidney Disease

Why is bone disease a consequence of chronic kidney disease (CKD) ?

A) The juxtaglomerular apparatus no longer synthesizes renin in CKD,which keeps calcium phosphate complexes from mineralizing.
B) The basement membrane in Bowman capsule is damaged and calcium is lost in the glomerular filtrate.
C) When glomerular filtration declines,vitamin D activation decreases resulting in reduced calcium,which further leads to resorption of calcium from bone.
D) The synthesis of erythropoietin by peritubular fibroblasts because of reduced red blood cell survival.