The first protein marker to appear approximately 1 to 2 months after infection with the hepatitis B virus and also the last marker to disappear is the:

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The hepatitis B surface antigen (HBsAg) is the first protein marker that appears in the blood of an infected individual, approximately 1 to 2 months after infection. It is also the last marker to disappear, which can take several months or even years, depending on the individual's immune response. The anti-hepatitis B core antigen (anti-HBc) and anti-hepatitis B surface antigen (anti-HBs) are antibodies that develop after infection or vaccination and do not persist indefinitely in the blood. Hepatitis B immune globulin (HBIG) is a medication that contains antibodies to the virus and is used to prevent infection in individuals who have been exposed to the virus.

The First Protein Marker to Appear Approximately 1 to 2