You are appointed director of the county hospital cardiac laboratory and have been asked to identify individuals that might not respond well to platelet-inhibiting,clot-destroying drugs.Which of the following polymorphic genes would you be most interested in having genotyped to discover these individuals?

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CYP2C19 is the gene responsible for encoding an enzyme that metabolizes many drugs, including clopidogrel, a platelet-inhibiting, clot-destroying drug. Variants in this gene can lead to reduced function of the enzyme, resulting in decreased drug efficacy and increased risk of adverse cardiovascular events in patients treated with clopidogrel.

You Are Appointed Director of the County Hospital Cardiac Laboratory