Which of the following presents the greatest challenge to the development of a vaccine against HIV?

Question

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Surface antigens on HIV, specifically gp120 and gp41, are highly variable due to frequent mutations. This makes it difficult to create a vaccine that targets all strains of the virus. HIV also has the ability to evade the immune system by integrating into host cells and becoming dormant, further hindering vaccine development efforts. While options A and B are challenges, option C presents the greatest obstacle in developing a successful vaccine against HIV. Option D has some impact on vaccine trials, but it is not the most significant challenge in HIV vaccine development.

Which of the Following Presents the Greatest Challenge to the Development