One theory regarding immune tolerance and the development of autoimmunity states that during embryonic growth, some tissues are hidden behind anatomical barriers and cannot be surveyed by the developing immune system.Later in life, some of these tissues may be exposed to the immune system as a result of trauma or infection and the immune system responds by developing an immune reaction against these tissues as if they were foreign.This theory is the
A)theory of molecular mimmicry.
B)theory of immune deficiency.
C)forbidden clone theory.
D)sequestered antigen theory.

Question

Quizplus · Accepted Answer

This theory is known as the sequestered antigen theory, which proposes that immune tolerance to certain self-antigens that are hidden behind anatomical barriers during embryonic development can be disrupted when those antigens are exposed to the immune system later in life, leading to the development of autoimmune reactions.

One Theory Regarding Immune Tolerance and the Development of Autoimmunity