The cell's metabolic reactions involve the participation of _____ that lower the activation energy needed for the initiation of a reaction.

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Enzymes are biological catalysts that lower the activation energy needed for a reaction to occur. This allows metabolic reactions to occur at a faster rate and at a lower temperature compared to without enzymes. Cofactors and coenzymes are also involved in enzyme activity, but their main function is to assist in enzyme function rather than lower activation energy. Vitamins and ATP are not directly involved in lowering activation energy.

The Cell's Metabolic Reactions Involve the Participation of _____ That