Differentiate Between Primary and Secondary Microorganism Resistance,and Select the True

Differentiate between primary and secondary microorganism resistance,and select the true statement related to this issue of resistance.

A) Primary resistance occurs when the organism does not respond to the drug because it doesn't recognize the drug or it has a protective mechanism to destroy the drug on contact. Secondary resistance occurs when the organism initially responds to the drug but then stops responding or requires greater doses to kill the organism.
B) Primary resistance occurs when the organism initially responds to the drug but then stops responding or requires greater doses to kill the organism. Secondary resistance occurs when the organism does not respond to the drug because it doesn't recognize the drug or it has a protective mechanism to destroy the drug on contact.
C) Using multiple drugs in combination at the same time speeds the development of resistance to a single drug primarily because of their antagonistic effect on each other.
D) None of these are correct.