Select the statement that best explains the mechanism of action of alendronate (Fosamax) ,pamidronate (Aredia) ,risedronate (Actonel) ,and zoledronate (Reclast) .
A) The nonnitrogen bisphosphonates are attracted to bone calcium and have greater resorption inhibition potency. These drugs [alendronate (Fosamax) , pamidronate (Aredia) , risedronate (Actonel) , and zoledronate (Reclast) ] compete with osteoclast ATP, causing the cells to die; thus, bone resorption decreases.
B) The nonnitrogen bisphosphonates [alendronate (Fosamax) , pamidronate (Aredia) , risedronate (Actonel) , and zoledronate (Reclast) ] compete with osteoclast ATP, causing the cells to die; thus, bone resorption decreases.
C) The nitrogen bisphosphonates are more readily attracted to bone calcium and have greater resorption inhibition potency. These drugs [alendronate (Fosamax) , pamidronate (Aredia) , risedronate (Actonel) , and zoledronate (Reclast) ] prevent protein synthesis in the osteoclast cell membrane by interrupting the HMG-CoA reductase pathway.
D) None of these are correct.
Correct Answer:
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