Select the statement that best explains the reason why patients taking warfarin (Coumadin) should take only the lowest effective dose of acetaminophen for short term therapy only.
A) Acetaminophen has been reported to increase the anticoagulant effect of warfarin. The mechanism is the inhibition of the liver enzyme metabolism of warfarin, resulting in increased circulating anticoagulant.
B) Acetaminophen has been reported to decrease the anticoagulant effect of warfarin. The mechanism is the stimulation of the liver enzyme metabolism of warfarin, resulting in decreased circulating anticoagulant.
C) Acetaminophen has been reported to increase the anticoagulant effect of warfarin. The mechanism is the stimulation of the liver enzyme metabolism of warfarin, resulting in increased circulating anticoagulant.
D) None of these are correct.
Correct Answer:
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