Which of the following statements is true about thiazolidinedione as an insulin sensitizer?

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Troglitazone, the first drug in this class, has been withdrawn from the market due to safety concerns associated with the increased incidence of liver failure and death in patients taking the drug. There is a special cautionary warning about the use of these drugs in patients with congestive heart failure. Common adverse effects in this class include fluid retention and weight gain. Rosiglitazone should be discontinued if ALT levels remain at more than three times the upper limit of normal on repeated assay.

Which of the Following Statements Is True About Thiazolidinedione as an Insulin