Oral Formulations of Opioid Drugs Should Never Be Chewed Because

Oral formulations of opioid drugs should never be chewed because:

A) chewing could achieve a higher blood level than expected with an increase in side effects.
B) chewing could achieve a lower blood level than expected with a decrease in desired effects.
C) chewing could decrease the absorption of the drug.
D) chewing could result in adverse food-drug interactions.