Long-acting benzodiazepines are metabolized by the liver to form active metabolites,which are inactivated after forming conjugates with _____.

Question

Quizplus · Accepted Answer

The long-acting benzodiazepines have half-lives of more than 20 hours. Also, during metabolism by the liver, they form active metabolites, which generally have long half-lives. When taken on a daily basis, these drugs produce effects that can last several days, due to accumulation of active metabolites in the body. Eventually, the active metabolites are conjugated with glucuronic acid. This step inactivates them and allows them to be excreted in the urine.

Long-Acting Benzodiazepines Are Metabolized by the Liver to Form Active