In Large Doses,barbiturates Lead to Cardiovascular and Central Nervous System

In large doses,barbiturates lead to cardiovascular and central nervous system depression.Select the reason for the occurrence of this depression.

A) Reduced activity in the medulla oblongata increases sympathetic control of the blood vessels, leading to hypertension, kidney failure, and irregular breathing.
B) Increased activity in the medulla oblongata decreases sympathetic control of the blood vessels, leading to hypotension, kidney failure, and irregular breathing.
C) Reduced activity in the medulla oblongata removes sympathetic control of the blood vessels, leading to hypotension, decrease in kidney function, irregular breathing, and hypoxia.
D) None of the above are correct.