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The Topical Anesthetic Procaine Has Been Shown to Inhibit the Action

Question 31

Multiple Choice

The topical anesthetic procaine has been shown to inhibit the action of sulfonamide antibiotics.Why does this inhibition of action occur?


A) Procaine is metabolized to p-aminobenzoic acid, which competes with the sulfonamides for the bacterial site of action.
B) Procaine is metabolized to p-aminobenzoic acid, which has an additive effect with the sulfonamides on the bacterial site of action.
C) Procaine is metabolized to p-aminobenzoic acid, which increases the patient's sensitivity to sulfonamides.
D) None of the above are true.

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