Both bupropion and varenicline impact the central nervous system (CNS).However,bupropion differs from varenicline in that it:

Name: Both bupropion and varenicline impact the central nervous system (CNS).However,bupropion differs from varenicline in that it:
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Bupropion is an antidepressant that affects mood and is claimed to reduce the CNS effects of nicotine withdrawal. Varenicline is a drug that is claimed to block nicotine receptors in the brain to prevent nicotine from exerting its full effects.

Both Bupropion and Varenicline Impact the Central Nervous System (CNS)