Identify the Major Pharmacokinetic Differences That Exist Between the Drug

Identify the major pharmacokinetic differences that exist between the drug effects of nonselective beta-blockers and selective beta-1 blockers that can alter their therapeutic responses.

A) Duration of action and extent of drug metabolism
B) Onset of action and extent of drug metabolism
C) Duration of action and extent of drug excretion
D) Onset of action and extent of drug absorption