Among the factors that affect drug distribution,the factor that plays the biggest role in determining the concentration of a drug that penetrates the brain by overcoming the blood-brain barrier is:

Question

Quizplus · Accepted Answer

An additional lipid barrier, the blood-brain barrier, protects the brain by restricting the passage of electrolytes and other water-soluble substances. Since the brain is composed of a large amount of lipid (nerve membranes and myelin), lipid-soluble drugs pass readily into the brain. As a general rule, then, a drug must have a certain degree of lipid solubility if it is to penetrate this barrier and gain access to the brain.

Among the Factors That Affect Drug Distribution,the Factor That Plays