One Reason That Malaria Continues to Be the World's Most

One reason that malaria continues to be the world's most significant infectious disease is because Plasmodium falciparum continues to develop resistance to the drugs that have been used to treat malaria.This is due to which of the following?

A) The antimalarial drugs cause mutations to occur in the mosquito.
B) Some mosquitoes have preexisting mutations that make them resistant to antimalarial drugs.
C) Some people have preexisting mutations that make them resistant to antimalarial drugs.
D) Some Plasmodium falciparum have preexisting mutations that make them resistant to antimalarial drugs.
E) The antimalarial drugs cause mutations to occur in Plasmodium falciparum.