What hypothesis did Boehm,et al.develop after testing mice (initially)and eventually humans?

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Boehm et al. hypothesized that because endostatin targets endothelial cells rather than the tumor cells directly, the tumor cells that are not initially killed may not develop resistance through natural selection. This is because the therapy is not directly acting on the tumor cells, but rather on the blood vessels that supply them, making it harder for the tumor cells to adapt and develop resistance.

What Hypothesis Did Boehm,et Al