The highly exergonic nature of ATP hydrolysis is explained by which of the following?
A) the resulting orthophosphate is stabilized by resonance
B) electrostatic repulsion occurs between phosphate groups and the adenine base of ATP
C) the resulting product undergoes tautomerization to the keto form of ADP
D) the bond that is hydrolyzed is considered an ester of phosphoric acid, making it highly unstable
E) all of the above
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