Given the following peptide, what would be the overall charge at pH 5? Met-Glu-Ser-Arg-His-Phe-Pro-Asn-Ala-Glu-Cys-Ala-Ser
A)+2
B)+1
C)0
D)-1
E)-2

Question

Quizplus · Accepted Answer

At pH 5, the carboxylic acid groups of Glu and Asp will be deprotonated (-1), the amino groups of Lys, Arg, and His will be protonated (+1), and the side chain of Cys will be neutral. The net charge of the peptide will be 0.

Given the Following Peptide, What Would Be the Overall Charge