A typical Hill plot (log [YO2/(1- YO2) ] vs log PO2) for hemoglobin-oxygen binding does not yield a straight line as it does for myoglobin. Which of the following is the best explanation for this?
A) at high oxygen pressures, hemoglobin is in a low oxygen affinity state
B) at low oxygen pressures, hemoglobin is in a high oxygen affinity state
C) hemoglobin undergoes a transition from low affinity state under low oxygen pressure to a high affinity state under high oxygen pressure
D) hemoglobin undergoes a transition from high affinity state under low oxygen pressure to a low affinity state under high oxygen pressure
E) none of the above
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