Tay-Sachs Disease Is Caused by a Deficiency of __________ Which $\alpha$

Tay-Sachs disease is caused by a deficiency of __________ which results in an accumulation of ___________.

A) sphingomyelinase; sphingomyelin
B) ceramidase; ceramide
C) $\alpha$ -galactosidase A; GM₁ ganglioside
D) lysosomal N-acetylhexosaminidase A; GM₂ ganglioside
E) $\beta$ -glucosidase; glucosylceramide