Proteins destined for extracellular transport produce an N-terminal signal sequence. What binds to this sequence for endoplasmic reticulum association?
A)signal recognition particle
B)ribosome receptor protein
C)Sec61 docking protein
D)SNARE protein
E)none of the above

Question

Quizplus · Accepted Answer

The signal sequence binds to the signal recognition particle (SRP), which then interacts with the ribosome receptor protein on the endoplasmic reticulum membrane. This interaction targets the ribosome and nascent polypeptide chain to the Sec61 translocon, through which the protein is transported into the lumen of the endoplasmic reticulum. Therefore, of the options given, only choice A (signal recognition particle) is a protein that binds to the N-terminal signal sequence for endoplasmic reticulum targeting.

Proteins Destined for Extracellular Transport Produce an N-Terminal Signal Sequence