Which of the following substituted cyclohexanes has the most negative value of $\Delta$G^$\circ$ for ring flipping from the conformation in which the substituent is axial to the one where it is equatorial?

Question

Quizplus · Accepted Answer

Isopropylcyclohexane has the most negative value of F1F1F1S1F1F1F10GF1F1F1S1F1F1F10. This is because the isopropyl group is larger than the other substituents, and as it rotates from an axial to equatorial position, it experiences more steric hindrance, causing a greater decrease in energy for this conformational change.

Which of the Following Substituted Cyclohexanes Has the Most Negative Δ\DeltaΔ

Which of the Following Substituted Cyclohexanes Has the Most Negative $\Delta$