Which combination of carbonyl compound and amine can be used to prepare the following product by reductive amination?
A)only 1
B)only 3
C)only 1 and 3
D)only 2 and 4

Question

Which combination of carbonyl compound and amine can be used to prepare the following product by reductive amination? 
A)only 1 
B)only 3 
C)only 1 and 3 
D)only 2 and 4

Quizplus · Accepted Answer

The given product has an ethyl group attached to the nitrogen atom, indicating that the amine used in reductive amination should be ethylamine (or a derivative of ethylamine). From the given options, carbonyl compound 1 and 3 have the potential to react with ethylamine to form the desired product. Carbonyl compound 1 is an aldehyde and can react with ethylamine to form an imine intermediate. This intermediate can be reduced to the desired product using a reducing agent. Carbonyl compound 3 is a ketone and can undergo reductive amination to form the desired product using a reducing agent and ethylamine. Therefore, the best choice is only 1 and 3.

Which Combination of Carbonyl Compound and Amine Can Be Used