Which of the following amines can be prepared by ring opening of an epoxide with sodium amide followed by reduction?
A)only 1
B)only 1 and 2
C)only 1 and 4
D)1, 2, 3 and 4

Question

Which of the following amines can be prepared by ring opening of an epoxide with sodium amide followed by reduction? 
A)only 1 
B)only 1 and 2 
C)only 1 and 4 
D)1, 2, 3 and 4

Quizplus · Accepted Answer

Compounds 1 and 4 can be prepared by ring opening of the epoxide followed by reduction with sodium amide. Compound 2 is a tertiary amine and can't be prepared by ring opening of an epoxide. Compound 3 is a secondary amine, but the ring-opening reaction with sodium amide followed by reduction would lead to a primary amine, which is not compound 3. Thus, only compounds 1 and 4 can be prepared by the given method.

Which of the Following Amines Can Be Prepared by Ring