What is the pI of glycine? The structure and pKa values are shown below.

Question

Quizplus · Accepted Answer

The pI of an amino acid is the pH at which it is neutral (has no net charge). To determine the pI, we need to average the pKa values of the ionizable groups that become protonated and deprotonated as the pH changes. For glycine, there are two ionizable groups: the carboxyl group (pKa = 2.34) and the amino group (pKa = 9.60). To calculate the pI, we take the average of these pKa values: (2.34 + 9.60)/2 = 5.97. Therefore, the pI of glycine is 5.97, making choice B the correct answer.

What Is the PI of Glycine? the Structure and PKa