Which of the following is the first step in the mechanism of the reaction shown below?

Question

Quizplus · Accepted Answer

The reaction is a typical example of an acyl transfer reaction involving ATP, in which a carboxylate ion acts as a nucleophile attacking the γ-phosphorus of ATP. This forms a tetrahedral intermediate with the release of inorganic pyrophosphate. The tetrahedral intermediate then collapses with the cleavage of the thioester bond and the formation of a new acyl-thioester bond between the carboxylate and the thiol molecule. Therefore, option C is the first step in the mechanism of the reaction.

Which of the Following Is the First Step in the Mechanism