After 1616, Virginia shifted more and more scarce resources out of food production and into tobacco production. Hence, the economic cost of tobacco production included the sacrifice of food production.

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This statement is true. Virginia's shift towards tobacco production resulted in a decrease in food production, as resources such as labor and land were devoted to growing tobacco instead. This had an economic cost as the colony was then more reliant on importing food from other colonies or countries.

After 1616, Virginia Shifted More and More Scarce Resources Out