To become activated,which of the following requires being bound to a foreign antigen AND simultaneous costimulation?

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Quizplus · Accepted Answer

T cells require binding to a specific foreign antigen presented by an antigen-presenting cell (APC) through major histocompatibility complex (MHC) molecules. However, this alone is not enough for full activation. Simultaneous costimulation, often provided by the interaction of CD28 on T cells with B7 molecules on APCs, is required for full T cell activation. This ensures that T cells only become activated in the presence of both the antigen and a signal indicating that there is an ongoing infection or immune response. B cells also require foreign antigen binding for activation, but they do not always require costimulation. Interferon and MHC antigens are components of the immune system but are not directly involved in T or B cell activation.

To Become Activated,which of the Following Requires Being Bound to a Foreign