Imagine that a researcher treated a protein with a high concentration of a chaotropic agent.Which of the following is the most likely result of the treatment?
(I)Nonpolar portions of the protein become more soluble.
(II)The protein begins to denature ,
(III)The protein stability increases due to hydrophobic collapse,
A)I,II,III
B)I,II
C)II,III
D)I,III
E)II

Question

Quizplus · Accepted Answer

Chaotropic agents disrupt the hydrogen bonding and hydrophobic interactions in proteins, leading to denaturation. This would result in choice (II) only. While chaotropic agents can increase the solubility of hydrophobic molecules, this does not necessarily mean that nonpolar portions of the protein become more soluble (choice I). Additionally, hydrophobic collapse would not be expected to increase protein stability in the presence of a chaotropic agent (choice III).

Imagine That a Researcher Treated a Protein with a High