Which of the following is true regarding the reaction shown below? pyruvate + HCO₃⁻ + ATP $\rarr$ oxaloacetate + ADP + P_i
I.It requires the direct transport of oxaloacetate across the membrane.
II.It utilizes the malate-aspartate shuttle in some species.
III.It is essential for gluconeogenesis.
IV.Its reactants require the function of enzymes which are only found in the cytosol.

Question

Which of the following is true regarding the reaction shown below? pyruvate + HCO₃⁻ + ATP

\rarr

oxaloacetate + ADP + P_i
I.It requires the direct transport of oxaloacetate across the membrane.
II.It utilizes the malate-aspartate shuttle in some species.
III.It is essential for gluconeogenesis.
IV.Its reactants require the function of enzymes which are only found in the cytosol.

Quizplus · Accepted Answer

I is false as the reaction shown does not involve direct transport of oxaloacetate. II is true as malate-aspartate shuttle is involved in some species to transport oxaloacetate into the mitochondrial matrix. III is true as this reaction is a key step in gluconeogenesis. IV is false as the reactants (pyruvate, ATP) require the function of enzymes which are found in the cytosol as well as the mitochondrial matrix.

Which of the Following Is True Regarding the Reaction Shown →\rarr→

Which of the Following Is True Regarding the Reaction Shown $\rarr$