Which of the following best describe the mechanism of calmodulin (CaM)mediated activation? A)Ca²⁺ binding to calmodulin (CaM)results in conformational change that exposes a hydrophobic patch capable of binding to calcium sensitive protein kinase B)a conformational change induced by the binding of Ca²⁺ results in the release of the phosphate group in calmodulin (CaM) C)calmodulin (CaM)sensitive protein kinase dimerizes forming a joint active site capable of tightly binding Ca²⁺ D)phosphorylation of a tyrosine on calmodulin induced a conformational change that results in release of Ca²⁺ from the cytosol. E)none of the above.

Question

Quizplus · Accepted Answer

This option describes the mechanism of CaM-mediated activation, where Ca²⁺ binding to CaM results in a conformational change that exposes a hydrophobic patch capable of binding to calcium-sensitive protein kinase. This leads to the activation of the protein kinase, which then catalyzes downstream reactions. The other options do not accurately describe the mechanism of CaM-mediated activation.

Which of the Following Best Describe the Mechanism of Calmodulin