In which location listed below does the following reaction take place?
HMG-CoA → acetoacetate + Acetyl-CoA

Question

Quizplus · Accepted Answer

The conversion of HMG-CoA to acetoacetate and Acetyl-CoA occurs in the mitochondria of liver cells, as this is where ketone body synthesis occurs. The cytosol of cardiomyocytes and liver cells do not have the necessary enzymes for this conversion, and while ketone bodies can be produced in the mitochondria of heart cells, this specific reaction does not occur in that location. Therefore, the best choice is option D.

In Which Location Listed Below Does the Following Reaction Take