At low glucose concentrations (≤5mM),the majority of glucose produced by liver cells is due to the action of

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Glucose-6-phosphatase is responsible for the conversion of glucose-6-phosphate to glucose, which is the major pathway for glucose production in the liver at low glucose concentrations. Glucokinase and hexokinase are responsible for the phosphorylation of glucose, while AMP-dependent protein kinase (AMPK) and AMP-responsive tyrosine kinase are involved in glucose metabolism and energy regulation but do not directly contribute to glucose production in the liver.

At Low Glucose Concentrations (≤5mM),the Majority of Glucose Produced by Liver