A mutation that actually interfere with the function of the wild-type allele by specifying polypeptides that inhibit,antagonize,or limit the activity of the wild-type polypeptide is known as:
A) Loss of function mutation
B) Partial loss of function mutation
C) Recessive mutation
D) Gain of function mutation
E) Dominant negative mutation

Question

Quizplus · Accepted Answer

A dominant negative mutation is a type of mutation where the mutated gene product not only loses its function but also interferes with the function of the normal, wild-type gene product. This occurs when the protein produced from the mutated allele forms complexes with the normal protein, preventing it from functioning properly. Therefore, the mutated protein acts in a dominant fashion to interfere with the function of the normal protein.

A Mutation That Actually Interfere with the Function of the Wild-Type