The hydrogen bonding between the bases in the anticodons of tRNAs and the corresponding codons of mRNAs follows strict base-pairing rules only for the first two bases,while the base-pairing for the third base of the codon is less stringent.This is known as the:
A) Crick hypothesis
B) tRNA hypothesis
C) Wobble hypothesis
D) Central Dogma
E) None of these

Question

Quizplus · Accepted Answer

The statement refers to the Wobble hypothesis, which states that the hydrogen bonding between the anticodon and codon follows strict base-pairing rules for the first two bases, but for the third base, non-Watson-Crick base pairing is allowed, or "wobbled." This hypothesis was proposed by Francis Crick in 1966. Choices A, B, D, and E are incorrect because they do not relate to the specific phenomenon described in the statement.

The Hydrogen Bonding Between the Bases in the Anticodons of TRNAs