In the human genes for b-globin,a locus control region is characterized by
A) regulating the expression of the b-globin gene.
B) containing several DNAse I hypersensitive sites.
C) being about 15 kb in length.
D) acting upstream of the genes it affects.
E) All of these are correct.

Question

Quizplus · Accepted Answer

A locus control region (LCR) is a regulatory region that is responsible for controlling the expression of genes within a given locus. In the case of the human b-globin genes, the LCR is located upstream of the genes and is about 15 kb in length. The LCR contains several DNAse I hypersensitive sites, which are regions of chromatin that are more accessible to cleavage by DNAse I than other regions. These hypersensitive sites are thought to reflect regions of the chromatin that are actively involved in controlling gene expression. Therefore, all of the given choices are correct.

In the Human Genes for B-Globin,a Locus Control Region Is