Which of the following is true regarding the RB gene in relation to cancer and the cell cycle?
1)In many types of cancer both copies of the RB gene have been inactivated.
2)Inactivation of both copies of the RB gene impair the ability of the RB protein to bind E2F transcription factors.
3)pRB is phosphorylated through the action of cyclin-dependent kinases.

Question

Quizplus · Accepted Answer

All of the statements are true regarding the RB gene in relation to cancer and the cell cycle. The RB gene, when functioning properly, helps regulate the cell cycle. In many cancers, both copies of the RB gene are inactivated, leading to uncontrolled cell growth. The RB protein (pRB) normally inhibits cell cycle progression by binding to E2F transcription factors; when RB is inactivated, this inhibition is lost. pRB is regulated through phosphorylation by cyclin-dependent kinases, which modulates its ability to bind E2F and control the cell cycle.

Which of the Following Is True Regarding the RB Gene