How Are Intrinsic Drugs Different from Extrinsic Drugs

How are intrinsic drugs different from extrinsic drugs?

A) Intrinsic drugs are made by the body,whereas extrinsic drugs are made outside the body.
B) Intrinsic drugs are administered by the parenteral route,whereas extrinsic drugs are administered by the oral route.
C) Extrinsic drugs can only be applied to the skin or mucous membranes,whereas intrinsic drugs are taken internally.
D) Extrinsic drugs require a prescription for administration,whereas intrinsic drugs are available over-the-counter.