The major European disease that resulted in high rates of mortality among the natives of the New World was

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Smallpox was introduced to the New World by European explorers and wreaked havoc on the native population, causing mortality rates as high as 90%. Syphilis, yellow fever, and scurvy were also present in the New World before European contact, and avian flu did not exist in the 15th century.

The Major European Disease That Resulted in High Rates of Mortality