Which Factors) Produces) the Greatest Risk for Cleft Lip

Which factors) produces) the greatest risk for cleft lip?

A) Carrying the rare polymorphism of the TGFA gene
B) Having a family history with two affected first-degree relatives with cleft lip
C) Heavy maternal smoking plus carrying the high-risk allele of TGF
D) Having a family history with one individual with cleft lip
E) Heavy maternal smoking