An Adolescent Is Receiving Methotrexate Chemotherapy After Undergoing Limb-Salvage Surgery

An adolescent is receiving methotrexate chemotherapy after undergoing limb-salvage surgery for osteogenic sarcoma. Which statement by the adolescent indicates understanding of the purpose of leucovorin therapy after the methotrexate?

A) "I'm glad I only need one dose of the leucovorin."
B) "I don't have any pain so I won't need to take the leucovorin this time."
C) "I know I will be taking the leucovorin every 6 hours for about the next 3 days."
D) "I don't have any nausea so I won't need the leucovorin."