In regard to neurocognitive disorder due to Alzheimer's disease, having two genes for apolipoprotein (apo E4)

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Having two genes for apolipoprotein (apo E4) increases the risk of developing neurocognitive disorder due to Alzheimer's disease and decreases the average age of onset. This gene has been identified as a risk factor for Alzheimer's disease, particularly in individuals with two copies of the gene. This may be due to the fact that apo E4 is involved in the clearance of beta-amyloid, a protein that is associated with the development of Alzheimer's disease. Individuals with two copies of the gene may not be able to clear beta-amyloid as efficiently, leading to an increased risk of developing Alzheimer's disease and a younger age of onset.

In Regard to Neurocognitive Disorder Due to Alzheimer's Disease, Having