In their examination of whether RCTs exclude too many patients who normally seek treatment,Stirman and colleagues 2003)found that

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Stirman and colleagues (2003) found that there are likely to be efficacious treatment options for patients with comorbid disorders, indicating that RCTs may be excluding too many patients who normally seek treatment. They did not find that there were very few treatment options or uncertainty around suitable treatment options for patients with comorbid diagnoses, so choices A and B are incorrect.

In Their Examination of Whether RCTs Exclude Too Many Patients