What was the first major Supreme Court decision to define the relationship between the federal and state governments?

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McCulloch v. Maryland was the first major Supreme Court decision to define the relationship between the federal and state governments. The Court ruled that federal law takes precedence over state law, and that states cannot interfere with federal agencies or institutions. This case established the principle of federal supremacy, which has been a fundamental aspect of American government ever since.

What Was the First Major Supreme Court Decision to Define