Genomic imprinting in mice is mediated by the imprinting control region (ICR).In the paternal allele the:
A)enhancer element is methylated and serves as a buffer-insulator.
B)ICR is methylated,which allows H19 transcription.
C)ICR is not methylated,which allows H19 transcription.
D)ICR is not methylated,which allows Igf2 transcription.
E)ICR is methylated,which allows Igf2 transcription.

Question

Quizplus · Accepted Answer

In mice, the imprinting control region (ICR) when methylated on the paternal allele allows the transcription of Igf2. Methylation acts as a regulatory mechanism for gene expression in genomic imprinting, where the ICR's methylation status determines whether the Igf2 or H19 gene is expressed. In this case, methylation of the ICR on the paternal allele promotes Igf2 transcription, while the unmethylated ICR on the maternal allele allows H19 transcription.

Genomic Imprinting in Mice Is Mediated by the Imprinting Control